Endocannabinoid signaling modulates neurons of the pedunculopontine nucleus (PPN) via astrocytes Endocannabinoid signaling in the PPN
نویسندگان
چکیده
Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary „DE-MTA Lendület” Cellular Physiology Research Group of the Hungarian Academy of Sciences Department of Anatomy, Histology and Embryology; Faculty of Medicine, University of Debrecen, Debrecen, Hungary MTA-DE Neuroscience Research Group, Faculty of Medicine, University of Debrecen, Debrecen, Hungary MTA-DE-NAP BPain Control Research Group, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
منابع مشابه
Cholinergic and endocannabinoid neuromodulatory effects overlap on neurons of the pedunculopontine nucleus of mice.
The pedunculopontine nucleus (PPN) is a part of the reticular activating system and one of the main sources of the cholinergic fibers in the midbrain, while it is also subject to cholinergic modulation. This nucleus is known to be a structure that controls sleep-wake cycles, arousal, and locomotion. Neurons of the PPN are targets of several neuromodulatory mechanisms, which elicit heterogeneous...
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Slow inward currents (SICs) are known as excitatory events of neurons caused by astrocytic glutamate release and consequential activation of neuronal extrasynaptic NMDA receptors. In the present article we investigate the role of these astrocyte-dependent excitatory events on a cholinergic nucleus of the reticular activating system (RAS), the pedunculopontine nucleus (PPN). It is well known abo...
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The pedunculopontine nucleus (PPN) has previously been implicated in central command regulation of the cardiorespiratory adjustments that accompany exercise. The current study was executed to begin to address the potential role of the PPN in the regulation of cardiorespiratory adjustments evoked by muscle contraction. Extracellular single-unit recording was employed to document the responses of...
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gamma-Aminobutyric acid (GABA)ergic neurons are widely distributed in brainstem structures involved in the regulation of the sleep-wake cycle, locomotion, and attention. These brainstem structures include the pedunculopontine nucleus (PPN), which is traditionally characterized by its population of cholinergic neurons that have local and wide-ranging connections. The functional heterogeneity of ...
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modulates neuronal network dynamics in the human pedunculopontine nucleus. The pedunculopontine nucleus (PPN) is a part of the mesencephalic locomotor region and thought to play a key role in the initiation and maintenance of gait. Lesions of the PPN induce gait deficits, and the PPN has therefore emerged as a target for deep brain stimulation for the control of gait and postural disability. Ho...
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